| 摘要 |
The invention relates to pharmacology, medicine, veterinary medicine and to the pharmaceutical industry, in particular to a process for preparing original composite antimicrobial preparations for parenteral administration which have increased therapeutic effectiveness in the treatment of severe forms of tuberculosis and other infectious and inflammatory diseases. The proposed pharmaceutical composition comprises, as an active ingredient, antibiotic aminoglycoside or capreomicin and fine nanostructured silicon dioxide. The claimed process for preparing a pharmaceutical composition consists in mixing aminoglycoside or capreomicin antibiotic substance with highly disperse nanostructured silicon dioxide and is characterized in that the mixture of the above-mentioned substances in ratios of from 10:1 to 70:1 by weight, respectively, is subjected to mechanical processing by means of impact-abrading actions to increase the finely dispersed fraction weight portion. The mixture produced is used for preparing injection solutions. |
