发明名称 |
Modelo de aterosclerosis en cerdos |
摘要 |
<p>The present invention relates to a genetically modified pig as a model for studying atherosclerosis. The modified pig model displays one or more phenotypes associated with atherosclerosis. Disclosed is also a modified pig comprising a mutation in the endogenous ApoE gene or part thereof, LDL gene or part thereof, LDL receptor gene, or transcriptional or translational product or part thereof. The invention further relates to methods for producing the modified pig; and methods for evaluating the effect of a therapeutical treatment of atherosclerosis; methods for screening the efficacy of a pharmaceutical composition; and a method for treatment of a human being suffering from atherosclerosis are disclosed.</p> |
申请公布号 |
ES2547015(T3) |
申请公布日期 |
2015.09.30 |
申请号 |
ES20080715609T |
申请日期 |
2008.03.06 |
申请人 |
AARHUS UNIVERSITET |
发明人 |
FOG, JACOB BENTZON;SØRENSEN, CHARLOTTE BRANDT;KRAGH, PETER MICHAEL;MIKKELSEN, JACOB GIEHM;FALK, ERLING;BOLUND, LARS AXEL;CORYDON, THOMAS JUHL |
分类号 |
A01K67/027;C12N15/85;C12N15/877 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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