| 摘要 |
<p>The invention relates to the field of medicine and the chemical-pharmaceutical industry, and more particularly to the creation, production and use of a drug for the treatment (relief) of moderate to severe pain in different branches of medicine, particularly oncology.The aim of the invention is to create novel pharmaceutical compositions in the form of rectal suppositories containing nalbuphine or a salt thereof on various suppository bases, which are intended for treating (relieving) episodes of moderate to severe pain and have an effective and prolonged analgesic effect without having a laxative effect, and to provide a method for producing such compositions.In order to achieve this aim, it is proposed to use a nalbuphine salt in the form of suppositories on a hydrophilic emulsion base to treat moderate to severe pain. The pharmaceutical composition in suppository form for treating moderate to severe pain contains nalbuphine hydrochloride as active principle and a suppository base. As the suppository base, the composition contains a hydrophilic emulsion base that includes binders, a poloxamer, a filler, an emulsifier, propylene glycol and polyethylene oxide-400 as a solvent.</p> |
