| 发明名称 |
NOVEL THIOPHENE DERIVATIVES AS S1P1/EDG1 RECEPTOR AGONISTS |
| 摘要 |
<p>The invention relates to thiophene derivatives of formula (I)/their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunosuppressive agents wherein: A represents *—CO—CH═CH—, *—CO—CH2CH2—, *—CO—CH2—NH—, wherein the asterisks indicate the bond that is linked to the thiophene group of Formula (I), and R1-R3 are as defined in the claims.</p> |
| 申请公布号 |
EP1976512(B1) |
申请公布日期 |
2015.09.30 |
| 申请号 |
EP20070700562 |
申请日期 |
2007.01.10 |
| 申请人 |
ACTELION PHARMACEUTICALS LTD. |
发明人 |
BOLLI, MARTIN;LEHMANN, DAVID;MATHYS, BORIS;MUELLER, CLAUS;NAYLER, OLIVER;STEINER, BEAT;VELKER, JÖRG |
| 分类号 |
A61K31/381;A61K31/4245;A61P37/06;C07D333/22;C07D413/04 |
主分类号 |
A61K31/381 |
| 代理机构 |
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