| 摘要 |
The present invention relates to compound Formula (I) wherein: Formula (II) means a pyridazine, a pyrimidine or a pyrazine group, R independently represent a hydrogen atom, a halogen atom or a group chosen among a CN group, a hydroxyl group, a COOR1 group, a (C1-C3)fluoroalkyl group, a (C1-C3)fluoroalkoxy group, a NO2 group, a NR1R2 group, a (C1-C4)alkoxy group, a phenoxy group and a (C1-C3)alkyl group, said alkyl being optionally mono-substituted by a hydroxyl group, n is 1, 2 or 3, n is 1 or 2, R is a hydrogen atom, a halogen atom or a group chosen among a (C1-C3)alkyl group, a hydroxyl group, a COOR1 group, a NO2 group, a NR1R2 group, a morpholinyl or a morpholino group, a N-methylpiperazinyl group, a (C1-C3)fluoroalkyl group, a (C1-C4)alkoxy group and a CN group, Z is N or C, Y is N or C, X is N or C, W is N or C, T is N or C, U is N or C, for use as an agent for preventing, inhibiting or treating AIDS. Some of said compounds are new and also form part of the invention. |
| 主权项 |
1. A method of inhibiting replication of HIV-1 in a patient infected with HIV-1 comprising administering to a patient in need thereof an effective quantity of at least one compound of formula (I) or a pharmaceutically acceptable salt thereof to thereby inhibit replication of HIV-1: wherein:is an aromatic ring wherein V is C or N and when V is N, V is in an ortho, meta or para position with respect to Z such that the ring respectively forms a pyridazine, a pyrimidine, or a pyrazine,
R independently represents a hydrogen atom, a halogen atom, a —CN group, a hydroxyl group, a —COOR1 group, a (C1-C3)fluoroalkyl group, a (C1-C3)fluoroalkoxy group, a —NO2 group, a —NR1R2 group, a (C1-C4)alkoxy group, a phenoxy group, or a (C1-C3)alkyl group, said alkyl group being optionally mono-substituted by a hydroxyl group, n is 1, 2, or 3, n′ is 1 or 2, R′ is a hydrogen atom, a halogen atom, a (C1-C3)alkyl group, a hydroxyl group, a —COOR1 group, a —NO2 group, a —NR1R2 group, a morpholinyl or a morpholino group, a N-methylpiperazinyl group, a (C1-C3)fluoroalkyl group, a (C1-C4)alkoxy group, or a —CN group, R1 and R2 are independently a hydrogen atom or a (C1-C3)alkyl group, R″ is a hydrogen atom or a (C1-C4)alkyl group,
Z is C, V is C, Y is N, X is C, T is C, U is C, and W is C,Z is N, V is C, Y is C, X is N, T is C, U is C, and W is C,Z is N, V is N and is in the para position with respect to Z, Y is N, X is C, T is C, U is C, and W is C, orZ is N, V is C, Y is N, X is N, T is C, U is C, and W is C. |
