| 发明名称 | Compositions and methods for modulating HBV expression | ||
| 摘要 | Provided herein are oligomeric compounds with conjugate groups. In certain embodiments, the oligomeric compounds are conjugated to N-Acetylgalactosamine. | ||
| 申请公布号 | US9145558(B2) | 申请公布日期 | 2015.09.29 |
| 申请号 | US201514633491 | 申请日期 | 2015.02.27 |
| 申请人 | Isis Pharmaceuticals, Inc. | 发明人 | Prakash Thazha P.;Seth Punit P.;Swayze Eric E. |
| 分类号 | C07H21/02;C07H21/04;C12N15/13;C12N15/113 | 主分类号 | C07H21/02 |
| 代理机构 | Isis Pharmaceuticals, Inc. Patent Dept. | 代理人 | Isis Pharmaceuticals, Inc. Patent Dept. |
| 主权项 | 1. A compound comprising a modified oligonucleotide and a conjugate group, wherein the modified oligonucleotide consists of 20 contiguous nucleobases complementary to an equal length portion of nucleobases 1583 to 1602 of SEQ ID NO: 1, wherein the nucleobase sequence of the modified oligonucleotide is 100% complementary to SEQ ID NO: 1; and wherein the conjugate group comprises: | ||
| 地址 | Carlsbad CA US | ||