| 摘要 |
Disclosed are imidazopyridazinyl compounds of Formula (I): (I), or pharmaceutically salts and prodrugs thereof, wherein R3 is C2-4alkenyl or a cyclic group, and R1 and R2 are defined herein. Also disclosed are methods of using such compounds in the treatment of at least one CYP17 associated condition, such as, for example, cancer, and pharmaceutical compositions comprising such compounds.; |
| 主权项 |
1. A compound of Formula (I) or a pharmaceutically salt thereof; wherein: R1 is H, F, Cl, C1-4alkyl, or C1-4fluoroalkyl; R2 is H, halo, —CN, C1-4alkyl, C1-4fluoroalkyl, C1-4alkoxy, C1-4fluoroalkoxy, or —NRcRc; or R1 and R2 can be combined to form a benzo fused radical substituted with zero, 1, or 2 Ra; R3 is C2-4alkenyl or a cyclic group selected from C3-6cycloalkyl, C3-6cycloalkenyl, phenyl, naphthalenyl, or a 1- to 2-ring heteroaryl, wherein said cyclic group is substituted with zero to 3 Rb; each Ra is independently H, halo, —CN, C1-4alkyl, C1-4fluoroalkyl, C1-4alkoxy, and/or C1-4-fluoroalkoxy; each Rb is independently halo, C1-4alkyl, C1-4fluoroalkyl, C1-4alkoxy, C1-4fluoroalkoxy, —CN, C1-4hydroxyalkyl, C1-4thioalkyl, phenoxy, and/or —CH2O(phenyl); and each Rc is independently H, C1-4alkyl, and/or C3-6cycloalkyl, or both Rc together with the nitrogen atom to which they are attached form a 5- or 6-membered heterocyclyl group. |
