| 主权项 |
1. A compound of formula (I):wherein
each R1 is independently hydrogen, halogen, (C1-C4) alkyl, (C1-C4) alkoxy, (C1-C4) haloalkyl, hydroxy, —SO2NR6R7, —CN, —NR8SO2R9, —NR6R7, —CONR6R7, or —NR8COR9, wherein said (C1-C4) alkyl is optionally substituted by one or more groups selected from the group consisting of (C3-C7) cycloalkyl, hydroxyl, and —NR6R7 and wherein said (C1-C4) alkoxy is optionally substituted by one or more halogen atoms or (C3-C7) cycloalkyl groups, wherein,
R6 is hydrogen or (C1-C6) alkyl;R7 is hydrogen or (C1-C6) alkyl;R8 is hydrogen or (C1-C6) alkyl;R9 is hydrogen or (C1-C6) alkyl; n is an integer ranging from 1 to 3; each R2 is independently hydrogen, halogen, (C1-C4) alkyl, (C1-C4) alkoxy, (C1-C4)haloalkyl, hydroxy, —SO2NR10R11, —CN, or —NR12SO2R13, wherein said (C1-C4) alkyl and said (C1-C4) alkoxy are optionally substituted by one (C3-C7) cycloalkyl groups, wherein
R10 is hydrogen or (C1-C6) alkyl;R11 is hydrogen or (C1-C6) alkyl;R12 is hydrogen or (C1-C6) alkyl;R13 is hydrogen or (C1-C6) alkyl; m is an integer ranging from 1 to 3; R3 and R4 are different or the same and are independently:
H;—(C3-C7) cycloalkylcarbonyl;(C1-C6) alkyl, optionally substituted by one or more substituents selected from the group consisting of (C3-C7) cycloalkyl and (C5-C7) cycloalkenyl;(C1-C6) haloalkyl;(C3-C7) cycloalkyl;(C5-C7) cycloalkenyl;(C2-C6) alkenyl; and(C2-C6) alkynyl; or R3 and R4, together with the interconnecting atoms, form a 2,2-difluoro-1,3-dioxolane ring of formula (r) fused to the phenyl moiety which bears groups —OR3 and —OR4, wherein asterisks indicate carbon atoms shared with such phenyl ring: each R5 is independently CN, NO2, CF3, or halogen; k is 0 or an integer ranging from 1 to 3; L1 is selected from the group consisting of:
a bond,—(CH2)p-,[3]-(CH2)p—O-[4][3]-(CH2)p—NR10—(CH2)t-[4][3]-(CH2)p—OC(O)-[4][3]-(CH2)p—NR10C(O)-[4][3]-(CH2)p—NR10S(O2)-[4], and[3]-(CH2)p—S(O2)—N(R10)-[4]wherein [3] and [4] represent, respectively, the point of attachment of group L1 to the carbonyl group and to the ring W and whereinR10 is as described above,p is an integer ranging from 1 to 4 andt is an integer ranging from 1 to 4 W is a divalent group selected from the group consisting of arylene, (C5-C6)-heteroarylene, and saturated monocyclic (C3-C7)-heterocycloalkylene; L2 is a bond, —C(O)—, —S—, —S(O)—, —S(O)2—, or —(CH2)q— wherein q is 1 or 2; L3 is absent or is ortho-, meta-, or para-phenylene, or bivalent (C5-C6)-heteroarylene L4 is —(CH2)r-, [1]—(CH2)r—O-[2], [1]-OC(O)-[2], or [1]-C(O)O-[2] wherein r is 1 or 2 and [1] and [2] represent respectively the point of attachment of group L4 to the group L2 (or L3 when present) and to the phenyl ring; Z is NH, CH2 or O; and A is a nitrogen containing group which is: a group (a) which is —(CH2)s—NR16R17 wherein s is an integer ranging from 1 to 4 and R16 and R17 are independently hydrogen or (C1-C4) alkyl; and a group (b) which is a saturated monocyclic, bicyclic or tricyclic heterocyclic ring system optionally substituted by one or two groups R18 which are at each occurrence independently (C1-C4) alkyl or benzyl, an N-oxide on the pyridine ring, or a pharmaceutically acceptable salt thereof. |
