| 主权项 |
1. A compound having formula Ia or a pharmaceutically acceptable salt thereof, wherein R1 is C1-4alkyl, C1-4fluoroalkyl, C3-6cycloalkyl or C1-4alkoxy; R2 is H or halogen; R3 is H, halogen, NRbRc, C1-4alkyl, C1-4haloalkyl, C3-6cycloalkyl or C1-4hydroxyalkyl; Y is selected from the group consisting of a bond, —NH—, and —C(R5)(R6)—; R5 is H, OH, C1-4 alkoxy or halogen; R6 is H, C1-4alkyl, C1-4haloalkyl, C3-6cycloalkyl or C1-4hydroxyalkyl; Z is (a) an optionally benzofused C3-6cycloalkyl optionally substituted with 1-5 groups independently selected from C1-4alkyl, ORa, CO2Ra, and CONRbRc; Ra is selected from the group consisting of:
(i) H;(ii) C1-8 alkyl;(iii) a group of the formula -M-RCH, wherein
M is a bond or —(CH2)1-2-;RCH is aryl or carbocycle optionally substituted with 1-3 groups independently selected from halo, C1-4alkyl, or C1-4alkoxy;(iv) a group of the formula —(CH2)1-2—Re or —(CH2)2—O—(CH2)2—Re wherein
Re is CO2Re1, C(O)N(Re2)2, or —O(CO)Re1;
Re1 is C1-4alkyl; andRe2 is H or C1-4alkyl;(v) a group of the formula —(CH2)2—Rf,
Rf is OH, —OC1-4alkyl, NH2, —N(H)(C1-4alkyl) or N(C1-4alkyl)2;(vi) a group of the formula wherein
Rg is H or C1-4alkyl; andRh is C1-4alkyl, C3-6cycloalkyl, or phenyl; and,(vii) a group of the formula wherein Rg and Rh are as set forth above; Rb and Rc are each independently selected from H and C1-4alkyl. |
