| 摘要 |
Disclosed are processes for preparing [(3-hydroxypyridine-2-carbonyl)amino]-alkanoic acids, derivatives, inter alia, 5-aryl substituted and 5-heteroaryl substituted [(3-hydroxypyridine-2-carbonyl]amino}acetic acids. Further disclosed are methods for making prodrugs of [(3-hydroxypyridine-2-carbonyl)-amino]acetic acids, for example, [(3-hydroxypyridine-2-carbonyl]amino}acetic acid esters and {[3-hydroxypyridine-2-carbonyl]amino}acetic acid amides. The disclosed compounds are useful as prolyl hydroxylase inhibitors or for treating conditions wherein prolyl hydroxylase inhibition is desired. |
| 主权项 |
1. A process for preparing a compound having the formula: wherein R1 is chosen from: L is a linking unit having the formula:
—(CR7aR7b)n—R7a and R7b are each independently:i) hydrogen; orii) C1-C6 linear, C3-C6 branched or C3-C6 cyclic alkyl;R8 is chosen from hydrogen, methyl, or ethyl; andthe index n is an integer from 1 to 4;or a pharmaceutically acceptable salt thereof,comprising:A) reacting a boronic acid with a 3,5-dihalo-2-cyanopyridine having the formula: each Z is independently chloro or bromo, in the presence of a catalyst, to form a 5-aryl or 5-heteroaryl-3-halo-2-cyanopyridine having the formula: B) reacting the 5-aryl or 5-heteroaryl-3-halo-2-cyanopyridine formed in step (A) with an alkoxide anion having the formula:
⊖OR2 wherein R2 is C1-C12 linear alkyl or C3-C12 branched alkyl, to form a 5-aryl or 5-heteroaryl-3-alkoxy-2-cyanopyridine having the formula: C) reacting the 5-aryl or 5-heteroaryl-3-alkoxy-2-cyanopyridine formed in step (B) with an acid to form a 5-aryl or 5-heteroaryl-3-hydroxy-2-carboxypyridine having the formula:and
D) reacting the 5-aryl or 5-heteroaryl-3-hydroxy-2-carboxypyridine formed in step (C) with an amino acid having the formula: wherein the boronic acid is chosen from 2-fluorophenylboronic acid, 3-fluorophenylboronic acid, 4-fluorophenylboronic acid, 2-chlorophenylboronic acid, 3-chlorophenylboronic acid, 4-chlorophenylboronic acid, 2-methylphenylboronic acid, 3-methylphenylboronic acid, 4-methylphenylboronic acid, 2-methoxyphenylboronic acid, 3-methoxyphenyl-boronic acid, 4-methoxyphenylboronic acid, 2-cyanophenylboronic acid, 3-cyano-phenylboronic acid, 4-cyanophenylboronic acid, 2-nitrophenylboronic acid, 3-nitrophenylboronic acid, 4-nitrophenylboronic acid, 2-trifluoromethylphenylboronic acid, 3-trifluoromethylphenylboronic acid, 4-trifluoromethylphenylboronic acid, 2-carbamoylphenylboronic acid, 3-carbamoylphenylboronic acid, 4-carbamoylphenyl-boronic acid, 2-(pyrrolidine-1-carbonyl)phenylboronic acid, 3-(pyrrolidine-1-carbonyl)phenylboronic acid, 4-(pyrrolidine-1-carbonyl)phenylboronic acid, 2-(cyclopropanecarbonylamino)phenylboronic acid, 3-(cyclopropanecarbonyl-amino)phenylboronic acid, 4-(cyclopropanecarbonylamino)phenylboronic acid, 3-chloro-6-methylphenylboronic acid, and 2-chloro-5-methylphenylboronic acid. |
