Oxadiazole compound and preparation method thereof, pharmaceutical composition and use thereof

摘要

The present invention provides an anti-Coxsackie virus oxadiazole compound as represented by formula (I), or the pharmaceutically acceptable salt thereof, a preparation method, a pharmaceutical composition, and use thereof, wherein R is CH3 or CF3; R′ and R″ are respectively H, alkyl or halogen; A is O or S; n is a number from 1 to 6; X is O, S or NH; Y is alkyl, unsubstituted cycloalkyl, mono-substituted cycloalkyl, disubstituted cycloalkyl, poly-substituted cycloalkyl, unsubstituted aryl, mono-substituted aryl, disubstituted aryl, poly-substituted aryl, unsubstituted 5-6 membered heterocyclyl, mono-substituted 5-6 membered heterocyclyl, disubstituted 5-6 membered heterocyclyl, or poly-substituted 5-6 membered heterocyclyl. Compared to prior art, the oxadiazole compound of the present invention has excellent anti-Coxsackie virus activity, lower toxicity and high safety.;

主权项

1. An oxadiazole compound having use as anti-coxsackie as represented by formula (I) or pharmaceutically acceptable salt thereof, wherein Y is C1-C6 alkyl, unsubstituted C3-C10 cycloalkyl, mono-substituted C3-C10 cycloalkyl, disubstituted cycloalkyl, poly-substituted C3-C10 cycloalkyl, unsubstituted aryl, mono-substituted aryl, disubstituted aryl, poly-substituted aryl, unsubstituted thienyl, unsubstituted furyl, unsubstituted pyrrolyl, unsubstituted isoxazolyl, unsubstituted oxazolyl, unsubstituted pyridazinyl, unsubstituted pyrazinyl, unsubstituted thiazolyl, unsubstituted isothiazolyl, unsubstituted triazolyl, unsubstituted tetrazolyl, unsubstituted thiadiazolyl, unsubstituted oxadiazolyl, unsubstituted imidazolyl, unsubstituted pyrazolyl, unsubstituted pyridyl, unsubstituted pyrimidinyl, monosubstituted thienyl, monosubstituted furyl, monosubstituted pyrrolyl, monosubstituted isoxazoyl, monosubstituted oxazolyl, monosubstituted pyridazinyl, monosubstituted pyrazinyl, monosubstituted thiazolyl, monosubstituted isothiazolyl, monosubstituted triazolyl, monosubstituted tetrazolyl, monosubstituted thiadiazolyl, monosubstituted oxadiazolyl, monosubstituted imidazolyl, monosubstituted pyrazolyl, monosubstituted pyridyl, mono-substituted pyrimidinyl, disubstituted thienyl, disubstituted furyl, disubstituted pyrrolyl, disubstituted isoxazoly, disubstituted oxazolyl, disubstituted pyridazinyl, disubstituted pyrazinyl, disubstituted thiazolyl, disubstituted isothiazolyl, disubstituted triazolyl, disubstituted imidazolyl, disubstituted pyrazolyl, disubstituted pyrimidinyl, or poly-substituted 5-6 membered heterocyclyl wherein, R is CH3 or CF3; R′and R″ are methyl; A is O or S; n=2-3; and, X is O, S or NH.