| 发明名称 | Cancer therapy method | ||
| 摘要 | This invention describes a method for treating cancer by increasing the nuclear localization of the COMMD1 protein, which is associated with decreasing or blocking the proliferation of the cancer cell. The invention is also related to the use of agents that increase nuclear localization of the COMMD1 protein, in the manufacture of a medicament for cancer therapy. These agents can be peptides or proteins, among other compounds. The invention is also related to the optimization of a peptide, coming from the sequence HARIKPTFRRLKWKKYKGKFW, to increase the nuclear localization of the protein COMMD, and thus, to increase the antitumor effect of this peptide. | ||
| 申请公布号 | US9145554(B2) | 申请公布日期 | 2015.09.29 |
| 申请号 | US201314075276 | 申请日期 | 2013.11.08 |
| 申请人 | CENTRO DE INGENIERIA GENETICA Y BIOTECNOLOGIA | 发明人 | Guerra Valespi Maribel;Fernandez Masso Julio Raul;Musacchio Lasa Alexis;Gil Valdes Jeovanis;Reyes Acosta Osvaldo;Oliva Arguelles Brizaida Maylin |
| 分类号 | C07K7/08;C12N15/11;A61K31/505;A61K31/513;A61K33/24;A61K38/10;A61K45/06;A61K48/00;G01N33/574;A61K38/17 | 主分类号 | C07K7/08 |
| 代理机构 | Hoffmann & Baron, LLP | 代理人 | Hoffmann & Baron, LLP |
| 主权项 | 1. A method for treating cancer, comprising contacting a cancer cell with a polypeptide consisting of the amino acid sequence of SEQ ID NO: 3, wherein the amino acids at positions 6 and 11 are D amino acids. | ||
| 地址 | La Habana CU | ||