Crystalline salts of R)-3-[6-amino-pyridin-3-yl]-2-(1-cyclohexy1-1H-imidazol-4-yl)-propionic acid

摘要

The invention relates to a sodium salt of (R)-3-[6-amino-pyridin-3-yl]-2-(1-cyclohexyl-1H-imidazol-4-yl)-propionic acid which is in a crystalline form or in at least partially crystalline form as a monohydrate or anhydrate, as well as a process for the preparation of the same, methods of using such salt to treat subjects suffering from conditions which can be ameliorated by the administration of an inhibitor of the enzyme TAFIa (activated thrombin-activatable fibrinolysis inhibitor).

主权项

1. Sodium salt of (R)-3-[6-amino-pyridin-3-yl]-2-(1-cyclohexyl-1H-imidazol-4-yl)-propionic acid as a monohydrate in a crystalline form or in at least partially crystalline form, wherein the crystalline salt exhibits in an X-ray powder diffraction pattern measured in transmission with CuKα1 radiation at room temperature a characteristic reflection at degrees 2 theta of 22.2, 16.5 and 6.3 , each ±0.2 degrees 2 theta.