Process for the preparation of 2-deoxy-2-fluoro-2-methyl-d-ribofuranosyl nucleoside compounds

摘要

Disclosed herein is a process for the preparation of (2’R)-2’-deoxy-2’-fluoro-2’-methylcytidine derivatives of formula (I), which involves a step of coupling of the silylated N-benzoyl cytosine with the (2R)-2-deoxy-2-fluoro-2-methyl-D-ribofuranosyl chloride, wherein R1 is selected from C1-4-alkyl is described. The (2’R)-2’-deoxy-2’-fluoro-2’-methylcytidine derivatives of formula (I) have the potential to be useful as prodrugs for potent inhibitors of the Hepatitis C Virus (HCV) NS5B polymerase.