发明名称 |
Dpp-iv inhibitor combined with a further antidiabetic agent, tablets comprising such formulations, their use and process for their preparation |
摘要 |
<p>Disclosed is a granulation liquid consisting of: a DPP-4 inhibitor, which has a free or primary amino group, namely 1-[(4-methylquinazolin-2-yl)methyl]-3-methyl-7-(2-butyn-1-yl)-8-(3-(R)-amino-piperidin-1-yl)-xanthine (Linagliptin / BI-1356); and L-arginine, a binder (preferably copovidone) and a solvent or mixture of solvents (preferably water). Also disclosed is the use of the granulation liquid as defined above for the preparation of granules comprising linagliptin, and metformin hydrochloride, L-arginine, a binder and a solvent filler.</p> |
申请公布号 |
NZ619580(A) |
申请公布日期 |
2015.09.25 |
申请号 |
NZ20090619580 |
申请日期 |
2009.04.02 |
申请人 |
BOEHRINGER INGELHEIM INTERNATIONAL GMBH |
发明人 |
FRIEDL THOMAS;BRAUN MICHAEL;EGUSA KENJI;MARUYAMA MEGUMI;NISHIOKA TAKAAKI;FUJITA HIKARU |
分类号 |
A61K45/06;A61K31/4523;A61K31/517;A61K31/522;A61K47/18;A61P3/10;C07D211/56;C07D239/74;C07D473/04 |
主分类号 |
A61K45/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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