摘要 |
<p>The disclosure relates to the 2-imidazolidinone-ethyl-piperazine derivative compounds represented by the formulae shown herein. Also described is a composition comprising: A sterol, A neutral lipid, A PEG or PEG-modified lipid, and A lipid of formula (I) which contains piperazine or amine moieties. Also disclosed are methods of making compounds such as 1-cyanomethyl-4-(2- ((cyanomethyl)amino)ethyl)piperazine. The lipid composition is useful for therapeutic agent delivery of nucleic acids as well as nucleic acid-lipid particle compositions.</p> |