| 摘要 |
<p>An attempt was made to study the pharmacological property and phytochemical constituents of Syzygium mundagam. From the in vitro antioxidant and antidiabetic study in animal models it was concluded that the bark extract of the plant could be the best candidate for the isolation of compounds for the said activity. Hence five new compounds were isolated for the first time from the plant with the help of TLC and column chromatography. Various solvent combinations of toluene, chloroform, ethyl acetate, methanol, acetone, acetic acid used for the isolations are developed for the first time for these isolations. Compound 1 (l,5b,7,7,13 - pentamethylicosahydro - lH-cyclopenta[a]chrysene-3a,9 - dicarboxylic acid), compound 2 (ll^l-dimethoxy-^^ea^b^^-pentamethyl^-oxo^^^^a^^a^b, 7,8,8a, 9,10,11,12,12a, 14,14a, 14b-octadecahydro-lH-phenanthro [1,2-c] chromene-8a-carboxamide), compound 3 (2-(4-hydroxy-5,5-dimethoxy-2,3,3-trimethylcyclohexyl)-3-methyl-4-oxochroman-5,7-dicarboxylic acid), compound 4 (l,7,7,13-tetramethoxy-5b-methylicosahydro-lH-cyclopenta[a]chrysene-3a,9-dicarboxylic acid) and compound 5 [(2Z,6Z,10E,14E,18E,22E) -2,23-dimethoxy - 6,10,15,19 - tetramethyltetracosa-2,6,10, 14,18,22-hexaene] could be taken as the novel source of phytocompounds for the development of drug against diabetes.</p> |
