摘要 |
Disclosed herein are a composition and unit dosage form for the treatment of hepatitis C virus (HCV) infection comprising GS-7977 and at least one pharmaceutically acceptable excipient, as well as methods for making said composition and unit dosage form. Also disclosed herein is a method of treating a subject, preferably a human, infected with hepatitis C virus, said method comprising administering to the subject for a time period an effective amount of GS-7977 and an effective amount of ribavirin. In one aspect, the method comprises administering to the subject an interferon-free treatment regimen comprising an effective amount of GS-7977 and an effective amount of ribavirin. In a particular aspect, the method is sufficient to produce an undetectable amount of HCV RNA in the subject for at least 12 weeks after the end of the time period. |
申请人 |
GILEAD PHARMASSET LLC |
发明人 |
CLEARY, DARRYL, G.;REYNOLDS, CHARLES, J.;BERREY, MIRIAM, MICHELLE;HINDES, ROBERT, G.;SYMONDS, WILLIAM, T.;RAY, ADRIAN, S.;MO, HONGMEI;HEBNER, CHRISTY, M.;OLIYAI, REZA;ZIA, VAHID;STEFANIDIS, DIMITRIOS;PAKDAMAN, ROWCHANAK;CASTEEL, MELISSA, JEAN |