Amine derivatives as potassium channel blockers

摘要

Provided are amine derivative compounds of the general formula (I), where the variables are as defined in the specification. Examples of the compounds include N-[cyclopropyl(4-methoxyphenyl)methyl]-3-(4-fluorophenyl)-N-(pyridin-2-ylmethyl)butanamide and 2-(4-Fluorophenylsulfonyl)-N-(2-phenylpropan-2-yl)-N-(pyridine-2-ylmethyl)acetamide. The compounds are modulators of potassium (K+) channels, particularly Kv1.3 channels in T cells. The compounds may be useful in the treatment of autoimmune and inflammatory diseases such as multiple sclerosis.