| 摘要 |
<p>Disclosed is an antibody that binds TGF-alpha and Epiregulin, comprising a light chain and a heavy chain, wherein the light chain variable region comprises LCDR1, LCDR2, and LCDR3, and the heavy chain variable region comprises amino acid sequences HCDR1, HCDR2, and HCDR3, wherein LCDR1 is RSSQSIVHSTGNTYLE, LCDR2 is KVSNRFS, LCDR3 is FHGTHVPYT, HCDR1 is GYTFTDAYIN, HCDR2 is WIWPGPVITYYNPKFKG, and HCDR3 is REVLSPFAY. Also disclosed is the use of such an antibody in the manufacture of a medicament for the treatment of diabetic nephropathy.</p> |
