DOUBLE-STRANDED OLIGONUCLEOTIDE MOLECULES TO DDIT4 AND METHODS OF USE THEREOF

摘要

Provided herein are double stranded nucleic acid molecules, compositions comprising same and methods of use thereof for the treatment of a subject wherein expression of DDIT4 is associated with the etiology or progression of a disease or disorder in the subject. The compounds are preferably chemically synthesized and modified dsRNA molecules.

主权项

1. A double-stranded nucleic acid molecule capable of targeting DDIT4 mRNA (SEQ ID NO:1); wherein
(a) the double-stranded nucleic acid molecule includes a sense strand and an antisense strand and wherein each strand is independently 18 to 49 nucleotides in length; (b) a 18 to 49 nucleotide sequence of the antisense strand is complementary to a 18 to 49 consecutive nucleotide sequence in the DDIT4 mRNA; (c) a 18 to 49 nucleotide sequence of the sense strand is complementary to the antisense strand; and (d) the sense strand and the antisense strand comprise oligonucleotide sequence pairs set forth in SEQ ID NOS:3 and 12; SEQ ID NOS:4 and 13; SEQ ID NOS:5 and 14; SEQ ID NOS:6 and 15; SEQ ID NOS:7 and 16; SEQ ID NOS:8 and 17; SEQ ID NOS:9 and 18; SEQ ID NOS:10 and 19; or SEQ ID NOS:11 and 20; or a pharmaceutically acceptable salt of such molecule.