发明名称 |
PD-1 ANTIBODIES IN COMBINATION WITH A CYTOKINE-SECRETING CELL AND METHODS OF USE THEREOF |
摘要 |
The present invention relates to a method of enhancing the anti-tumor response in a mammal. More particularly, the invention is concerned with combinations comprising a cytokine-secreting cell and an anti-PD-1 antibody, and methods of administering the combination for enhanced immune response to tumor cells in a patient with a cancer. |
申请公布号 |
US2015265705(A1) |
申请公布日期 |
2015.09.24 |
申请号 |
US201514733614 |
申请日期 |
2015.06.08 |
申请人 |
ADURO GVAX INC. ;E. R. SQUIBB & SONS, L.L.C. |
发明人 |
LI Betty;JOOSS Karin;KORMAN Alan J. |
分类号 |
A61K39/395;A61K38/19 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
|
主权项 |
1. A method of cancer immunotherapy comprising: administering a combination of a cytokine-expressing cellular immunotherapy and an antibody that specifically binds to human Programmed Death 1 (anti-PD-1) to a subject with cancer, wherein administration of the combination results in enhanced therapeutic efficacy relative to administration of the cytokine-expressing cellular immunotherapy or the anti-PD-1 antibody alone. |
地址 |
Berkeley CA US |