发明名称 |
KV2.1 CHANNEL-DERIVED PEPTIDES AND METHODS OF USE |
摘要 |
Peptides capable of interfering with the Kv2.1-mediated apoptotic K+ current surge that leads to neuronal cell death are described. The disclosed peptides are derived from the C-terminal region of Kv2.1, which mediates binding to the SNARE protein syntaxin. Disruption of Kv2.1 binding to syntaxin inhibits the apoptotic K+ current surge that leads to neuronal cell death. The present disclosure provides methods of inhibiting binding of Kv2.1 to syntaxin in a cell (in vitro or in vivo), such as for neuroprotection following cerebral ischemia, stroke, or traumatic brain injury, or during the course of a neurodegenerative disease, or any other condition associated with neuronal cell death. |
申请公布号 |
WO2015142826(A1) |
申请公布日期 |
2015.09.24 |
申请号 |
WO2015US20932 |
申请日期 |
2015.03.17 |
申请人 |
UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION |
发明人 |
AIZENMAN, ELIAS;MCCORD, MEGHAN |
分类号 |
C07K7/06;A61K38/08;A61K38/10;C07K7/08;C07K19/00 |
主分类号 |
C07K7/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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