| 主权项 |
1. A compound of Formula (I) or a pharmaceutically acceptable salt or prodrug thereof, wherein:
W is selected from the group consisting of: CR7 and N;A is selected from the group consisting of: —(CR8R9)p—(Y)q—(C(O))r—(CR10R11)s— and —(CR8R9)p—(C(O))r—(Y)q—(CR10R11)s—, wherein Y is selected from the group consisting of: O, S, NR12, each p and s are an integer independently selected from the group consisting of 0, 1, and 2, each q and r are an integer independently selected from the group consisting of 0 and 1, and p+q+r+s is an integer selected from the group consisting of 1, 2, and 3;Z1-Z2 is selected from the group consisting of N—C═ and C═C;X1 selected from the group consisting of: C═O, CF2 or SO2, PO2;X2 is selected from the group consisting of: NR13 and (CH2)t wherein t is an integer selected from the group consisting of: 0 and 1;D is selected from the group consisting of: a cycloalkyl, heterocycloalkyl, cycloalkenyl, heterocycloalkenyl, aryl or heteroaryl ring;R1, R4, R5, R6, R7, R8, R9, R10, and R11 are each independently selected from the group consisting of: H, halogen, OH, NO2, CN, NH2, optionally substituted C1-C12 alkyl, optionally substituted C2-C12 alkenyl, optionally substituted C2-C12 alkynyl, optionally substituted C1-C10 heteroalkyl, optionally substituted C3-C12 cycloalkyl, optionally substituted C3-C12 cycloalkenyl, optionally substituted C2-C12 heterocycloalkyl, optionally substituted C2-C12 heterocycloalkenyl, optionally substituted C6-C18 aryl, optionally substituted C1-C18 heteroaryl, optionally substituted C1-C12 alkyloxy, optionally substituted C2-C12 alkenyloxy, optionally substituted C2-C12 alkynyloxy, optionally substituted C1-C10 heteroalkyloxy, optionally substituted C3-C12 cycloalkyloxy, optionally substituted C3-C12 cycloalkenyloxy, optionally substituted C1-C12 heterocycloalkyloxy, optionally substituted C1-C12 heterocycloalkenyloxy, optionally substituted C6-C18 aryloxy, optionally substituted C1-C18 heteroaryloxy, optionally substituted C1-C12 alkylamino, SR14, SO3H, SO2NR15R16, SO2R14, SONR15R16, SOR14, COR14, COOH, COOR14, CONR15R16, NR15COR14, NR15COOR14, NR15SO2R14, NR15CONR15R16, NR15R16, and acyl;R2 and R3, are each independently selected from the group consisting of: H, OH, NO2, CN, NH2, optionally substituted C1-C12 alkyl, optionally substituted C2-C12 alkenyl, optionally substituted C2-C12 alkynyl, optionally substituted C1-C10 heteroalkyl, optionally substituted C3-C12 cycloalkyl, optionally substituted C3-C12 cycloalkenyl, optionally substituted C2-C12 heterocycloalkyl, optionally substituted C2-C12 heterocycloalkenyl, optionally substituted C6-C18 aryl, optionally substituted C1-C18 heteroaryl, optionally substituted C1-C12 alkyloxy, optionally substituted C2-C12 alkenyloxy, optionally substituted C2-C12 alkynyloxy, optionally substituted C1-C10 heteroalkyloxy, optionally substituted C3-C12 cycloalkyloxy, optionally substituted C3-C12 cycloalkenyloxy, optionally substituted C1-C12 heterocycloalkyloxy, optionally substituted C1-C12 heterocycloalkenyloxy, optionally substituted C6-C18 aryloxy, optionally substituted C1-C18 heteroaryloxy, optionally substituted C1-C12 alkylamino, SR14, SO3H, SO2NR15R16, SO2R14, SONR15R16, SOR14, COR14, COOH, COOR14, CONR15R16, NR15COR14, NR15COOR14, NR15SO2R14, NR15CONR15R16, NR15R16, and acyl; or R2 and R3 may be fused to form a 5 or 6 membered cycloalkyl, heterocycloalkyl, aryl or heteroaryl ring each of which may be optionally substituted;R12, R13, R15, R16, and R17 are each independently selected from the group consisting of: H, an N-protecting group, optionally substituted C1-C12 alkyl, optionally substituted C2-C12 alkenyl, optionally substituted C2-C12 alkynyl, optionally substituted C1-C10 heteroalkyl, optionally substituted C3-C12 cycloalkyl, optionally substituted C3-C12 cycloalkenyl, optionally substituted C1-C12 heterocycloalkyl, optionally substituted C1-C12 heterocycloalkenyl, optionally substituted C6-C18 aryl, and optionally substituted C1-C18 heteroaryl;R14 is selected from the group consisting of H, optionally substituted C1-C12 alkyl, optionally substituted C2-C12 alkenyl, optionally substituted C2-C12 alkynyl, optionally substituted C1-C10 heteroalkyl, optionally substituted C3-C12 cycloalkyl, optionally substituted C3-C12cycloalkenyl, optionally substituted C1-C12 heterocycloalkyl, optionally substituted C1-C12 heterocycloalkenyl, optionally substituted C6-C18 aryl, and optionally substituted C1-C18 heteroaryl;m is an integer selected from the group consisting of 0, 1, 2, 3, and 4;n is an integer selected from the group consisting of 1, 2, 3, 4, and 5; andm+n is an integer selected from the group consisting of 1, 2, 3, 4, and 5. |
