FIBER WADDING FOR FILLING BONE DEFECTS

摘要

A method for producing a flocculent three dimensional fibrous bioactive material using an electrospinning process includes electrospinning a biodegradable fiber by applying an electrical charge to a nozzle of an electrospinning apparatus such that a spinning solution contained therein is made into an electrospun fiber, which is attracted toward a collector container that is electrically grounded and is filled with an ethanol liquid; receiving the electrospun fiber emitted from the nozzle on a surface of the ethanol liquid in the collector container; recovering and drying the electrospun fiber to obtain the flocculent three dimensional fibrous bioactive material having a bulk density of from about 0.01 g/cm3 to about 0.1 g/cm3 as measured in accordance with JIS L 1097.

主权项

1. A method for producing a flocculent three dimensional fibrous bioactive material using an electrospinning process, comprising:
electrospinning a biodegradable fiber by applying an electrical charge to a nozzle of an electrospinning apparatus such that a spinning solution contained therein is made into an electrospun fiber, which is attracted toward a collector container that is electrically grounded and is filled with an ethanol liquid, wherein the spinning solution comprises a biodegradable polymer and a bioactive material dissolved in a solvent, wherein the electrospun fiber travels in a curve path to reach the collector container while the solvent of the spinning solution is evaporated in an electric field between the nozzle and the grounded collector container, wherein the electrospinning apparatus comprises a power supply, the nozzle, the collector container, and a grounded electrode soaked in the ethanol liquid in the collector container, wherein a distance between the nozzle and the grounded electrode is farther than a distance between the nozzle and the center of the collector container; receiving the electrospun fiber emitted from the nozzle on a surface of the ethanol liquid in the collector container such that the fiber sinks downward in the ethanol liquid and accumulated therein; recovering the electrospun fiber from the collector container; and drying the recovered electrospun fiber to obtain the flocculent three dimensional fibrous bioactive material having a bulk density of from about 0.01 g/cm3 to about 0.1 g/cm3 as measured in accordance with JIS L 1097.