发明名称 |
USE OF ELECTROPHILIC COMPOUNDS FOR INDUCING PLATELET PRODUCTION OR MAINTAINING PLATELET FUNCTION |
摘要 |
The present invention is directed to a method of inducing platelet production that includes contacting a megakaryocyte with an electrophilic compound under conditions effective to induce platelet production by the contacting megakaryocyte. Methods of treating a patient for low platelet levels, increasing the circulating half-life of platelets, and improving the quality (activity) of platelets are also disclosed herein, which involve administering the electrophilic compound to a patient an effective amount to achieve the desired effect. Pharmaceutical compositions and therapeutic systems are also disclosed for carrying out these therapeutic treatments. |
申请公布号 |
US2015265629(A1) |
申请公布日期 |
2015.09.24 |
申请号 |
US201514690872 |
申请日期 |
2015.04.20 |
申请人 |
Phipps Richard P.;Bernard Jamie J. |
发明人 |
Phipps Richard P.;Bernard Jamie J. |
分类号 |
A61K31/5575;A61K31/277;A61K31/19;A61K45/06;A61K31/215 |
主分类号 |
A61K31/5575 |
代理机构 |
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代理人 |
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主权项 |
1. A method of treating a patient for low platelet levels, the method comprising:
administering to a patient having a low platelet level an effective amount of a prostaglandin D2 that is suitable to cause an increase in platelet production by megakaryocytes. |
地址 |
Pittsford NY US |