| 主权项 |
1. A transdermal drug delivery patch comprising:
A) an active ingredient (AI) layer having a skin contacting surface and a non-skin contacting surface and comprising a pressure sensitive adhesive and the drug and B) an overlay adjacent the non-skin contacting surface of the AI layer, said overlay comprising: (i) a pressure sensitive adhesive (PSA) layer that is applied directly or indirectly to the AI layer and (ii) an elastomeric and permeable overlay covering, whereby: (i) at the end of an extended wear period, the patch causes cumulative moderate irritation plus significant irritation of less than 5%; or (ii) at the end of a seven day wear period, the patch exhibits meaningful degree of detachment over a seven day period of less than 20%. |
