Combination comprising a thioester and at least one esterase inhibitor, a process for increasing the bioavailability of the thioester by such combination, a pharmaceutical composition comprising said combination and kit comprising it

摘要

The present invention is directed to the combined administration of a thioester therapeutic agent (preferably of formula I) and at least one esterase inhibitor. Also provided are a pharmaceutical composition, package, and a kit comprising the aforementioned active ingredients, as well as a method for increasing the bioavailability of said thioester for the treatment and prophylaxis of a cardiovascular disorder.