发明名称 |
Tumor vaccination involving a humoral immune response against self-proteins |
摘要 |
The present invention relates to tumor immunotherapy, in particular to tumor vaccination, using chimeric proteins comprising all or a portion of a hepatitis B virus core antigen protein and an amino acid sequence comprising an epitope derived from the extracellular portion of a tumor-associated antigen. In particular, the present invention provides virus-like particles comprising said chimeric proteins, which are useful for eliciting a humoral immune response in a subject against the tumor-associated antigen, in particular against cells carrying said tumor-associated antigen on their surface, wherein the tumor-associated antigen is a self-protein in said subject. |
申请公布号 |
AU2011229518(B2) |
申请公布日期 |
2015.09.24 |
申请号 |
AU20110229518 |
申请日期 |
2011.03.09 |
申请人 |
UNIVERSITATSMEDIZIN DER JOHANNES GUTENBERG-UNIVERSITAT MAINZ;BIONTECH AG |
发明人 |
KLAMP, THORSTEN;SAHIN, UGUR;TURECI, OZLEM;KOSLOWSKI, MICHAEL;HILLER, THOMAS;SCHUMACHER, JENS |
分类号 |
C07K14/02;A61K39/29;C07K14/47 |
主分类号 |
C07K14/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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