Provided herein are fusion proteins comprising a first domain that specifically binds to the extracellular domain of a growth factor receptor, and a second domain that specifically binds to a cartilage matrix component, and pharmaceutical composition comprising these fusion proteins. Methods of treating musculoskeletal diseases using the fusion proteins and pharmaceutical composition disclosed herein are also provided.
申请公布号
AU2014240878(A1)
申请公布日期
2015.09.24
申请号
AU20140240878
申请日期
2014.03.28
申请人
MERRIMACK PHARMACEUTICALS, INC.
发明人
FLORINE, EMILY;KIRPOTIN, DMITRI B.;KOPESKY, PAUL;LUGOVSKOY, ALEXEY;RENNARD, RACHEL;SCHOEBERL, BIRGIT