SYSTEM PROVIDING PERHYDROLASE-CATALYZED REACTION

摘要

Described herein are packages for storing and dispensing multi-part tooth whitening formulations, comprising a deformable material configured to form two or more sealed chambers, e.g., wherein the first chamber contains a low viscosity liquid solution comprising an enzyme having perhydrolytic activity, and the second chamber contains a peroxide source and a at least one acyl donor substrate. Particular multi-part tooth whitening formulations using this principle and methods of use thereof are also provided.

主权项

1. A package comprising a deformable material configured to form at least two sealed chambers, the package comprising:
a first chamber; a second chamber; and optionally additional chambers,wherein the chambers are separated by one or more barriers which are frangible or tearable,wherein the first chamber contains a low viscosity liquid comprising a protein having perhydrolase activity which contains the catalytic domain of a member of the carbohydrate esterase family 7;the second chamber comprises a carboxy donor, andthe second chamber or optionally a third chamber comprises a peroxide source,such that when one or more barriers separating the chambers is compromised, permitting the low viscosity liquid solution to mix with the peroxide source and the carboxy donor, the protein having perhydrolase activity catalyzes a reaction between the peroxide source and the carboxy donor to form a peracid; andwherein the package has an opening means to provide an outlet through which the mixture can be dispensed.