| 发明名称 |
TRANSCRIPTION ACTIVATOR-LIKE EFFECTOR (TALE) - LYSINE-SPECIFIC DEMETHYLASE 1 (LSD1) FUSION PROTEINS |
| 摘要 |
Fusion proteins comprising a DNA binding domain, e.g., a TAL effector repeat array (TALE) or zinc finger array, and a catalytic domain comprising a sequence that catalyzes histone demethylation, and methods of use thereof. |
| 申请公布号 |
US2015267176(A1) |
申请公布日期 |
2015.09.24 |
| 申请号 |
US201314435065 |
申请日期 |
2013.10.11 |
| 申请人 |
THE GENERAL HOSPITAL CORPORATION |
发明人 |
Joung Jae Keith;Mendenhall Eric M.;Bernstein Bradley E.;Reyon Deepak |
| 分类号 |
C12N9/02;C07K14/195 |
主分类号 |
C12N9/02 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A fusion protein comprising
an engineered DNA-binding domain that binds specifically to a preselected target sequence, and a catalytic domain comprising a sequence that catalyzes histone demethylation. |
| 地址 |
Boston MA US |
