发明名称 |
CLARIFICATION OF MAMMALIAN CELL CULTURE |
摘要 |
Disclosed is an improved method for clarifying a cell culture during the manufacture of a protein. The method includes the step of transiently reducing the pH of a cell culture, followed by a holding step for a period of time, followed by the neutralization of the cell culture prior to clarification by centrifugation. |
申请公布号 |
WO2015142777(A1) |
申请公布日期 |
2015.09.24 |
申请号 |
WO2015US20862 |
申请日期 |
2015.03.17 |
申请人 |
REGENERON PHARMACEUTICALS, INC. |
发明人 |
ADAMS, BENJAMIN;TUSTIAN, ANDREW;BAK, HANNE |
分类号 |
C12N1/00;C12P21/08 |
主分类号 |
C12N1/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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