ANTAGONIST ANTIBODIES DIRECTED AGAINST CALCITONIN GENE-RELATED PEPTIDE AND METHODS USING SAME

摘要

The invention features methods for preventing or treating CGRP associated disorders such as vasomotor symptoms and/or headaches (e.g., migraine, cluster headache, and tension headache) by administering an anti-CGRP antagonist antibody. Compositions for use in the disclosed methods are also provided. Antagonist antibody G1 and antibodies derived from G1 directed to CGRP are also described.

主权项

1. A method of treating or reducing incidence of headache in a subject comprising administering to the subject on a plurality of days an amount of a monoclonal antibody that modulates the CGRP pathway, wherein the amount administered on each of the plurality of days is between 100-2000 mg.