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1. A compound having the structural formula of Structural Formula (I): or a pharmaceutically acceptable salt thereof, wherein:
R1 is a nitrogen-containing five- or six-member heteroaryl in which at least one ring nitrogen atom is adjacent to the carbon linking R1 to the amino group, optionally substituted with 1, 2, or 3 groups independently selected from the group consisting of:
hydroxyl;halogen;C1-C3 alkyl;hydroxyl (C1-C3)alkylamino, optionally linked to R1 through a carbonyl group;hydroxyl (C1-C3)dialkylamino, optionally linked to R1 through a carbonyl group;C1-C3 alkylamino, optionally linked to R1 through a carbonyl group;C1-C3 dialkylamino; optionally linked to R1 through a carbonyl group;(C1-C3)alkylamino(C1-C3)alkyl, optionally linked to R1 through a carbonyl group;(C1-C3)dialkylamino(C1-C3)alkyl, optionally linked to R1 through a carbonyl group;(C1-C3)alkylamino(C2-C3)alkoxyl, optionally linked to R1 through a carbonyl group;(C1-C3)dialkylamino(C2-C3)alkoxyl, optionally linked to R1 through a carbonyl group;(C1-C3)alkylamino(C2-C3)alkylamino, optionally linked to R1 through a carbonyl group;(C1-C3)dialkylamino(C2-C3)alkylamino, optionally linked to R1 through a carbonyl group;(C1-C3)alkylamino(C2-C3)dialkylamino, optionally linked to R1 through a carbonyl group(C1-C3)dialkylamino(C2-C3)dialkylamino, optionally linked to R1 through a carbonyl group;(C1-C3)alkoxyl(C2-C3)alkylamino, optionally linked to R1 through a carbonyl group;(C1-C3)alkoxyl(C2-C3)dialkylamino, optionally linked to R1 through a carbonyl group; anda three- to six-member heterocyclic ring containing 1 or 2 heteroatoms selected from O, N, and S; and, independently,
(1) optionally is substituted with (C1-C3)alkyl, (C1-C3) hydroxylalkyl, (C1-C3)alkoxyl(C1-C3)alkyl, or (C1-C3)alkylamino(C1-C3)alkyl and(2) optionally is linked to the five- or six-member heteroaryl through a carbonyl group;R2 is:
hydrogen;C1-C6 alkyl, optionally substituted with 1, 2, or 3 groups selected from hydroxyl, methoxyl, ethoxyl, methylamino, N,N-dimethyl amino, ethylamino, N,N-diethylamino, and methylsulfanyl;a three- to six-member cycloalkyl, optionally substituted with 1, 2, or 3 groups selected from hydroxyl, methoxyl, ethoxyl, methylamino, N,N-dimethyl amino, ethylamino, N,N-diethylamino, and methylsulfanyl;a three- to six-member heterocyclic ring, optionally substituted with 1, 2, or 3 groups selected from hydroxyl, C1-C3 alkyl, methoxyl, ethoxyl, methylamino, N,N-dimethyl amino, ethylamino, N,N-diethylamino, and methylsulfanyl;phenyl, optionally substituted with 1, 2, or 3 groups selected from hydroxyl, methoxyl, ethoxyl, methylamino, N,N-dimethyl amino, ethylamino, N,N-diethylamino, and methylsulfanyl; orheteroaryl, optionally substituted with 1, 2, or 3 groups selected from hydroxyl, methoxyl, ethoxyl, methylamino, N,N-dimethyl amino, ethylamino, N,N-diethylamino, and methylsulfanyl; andR3 is:
halogen;C1-C6 alkyl;C1-C6 hydroxylalkyl;C1-C6 alkylcarbonyl;C1-C6 perfluoroalkyl;C3-C6 cycloalkyl;C2-C6 alkenyl, optionally substituted with 1, 2, or 3 substituents selected from the group consisting of C1-C3 alkoxyl, C1-C3 alkoxylcarbonyl, and trifluoromethyl;C2-C6 alkynyl, optionally substituted with 1, 2, or 3 substituents selected from the group consisting of C1-C3 alkoxyl, hydroxyl, C1-C6 alkyl, trifluoromethyl;phenyl, optionally substituted with 1, 2, or 3 substituents selected from the group consisting of halogen, C1-C3 alkoxyl, and trifluoromethyl; anda five- to six-member heteroaryl, optionally substituted with 1, 2, or 3 substituents selected from the group consisting of halogen, C1-C3 alkoxyl, and trifluoromethyl. |
