BICYCLIC PYRIMIDINES AND USE THEREOF AS ANTIOXIDANTS AND CYTOPROTECTORS

摘要

The invention relates to medicine, particularly to neurology and cardiology, and also to surgery and traumatology, and specifically relates to medicinal agents exhibiting cytoprotective activity in the presence of ischemia-reperfusion, chronic oxidative stress and chemical intoxication. A compound which is a derivative of bicyclic pyrimidines is used as an activator of the transcription factor Nrf2. The compounds I can be used preventively for enhancing the defensive capabilities of the body prior to working with toxic chemicals and high doses of radiation.