| 发明名称 |
ANTIBODIES WITH ENGINEERED IGG FC DOMAINS |
| 摘要 |
Antibody Fc polypeptides are provided that efficiently bind to both Fcγ and Fcα receptors. In certain aspects, a Fc polypeptide comprises a chimeric IgG CH2 domain having a α1 loop from IgA and an IgA CH3 domain. Recombinant antibodies comprising Fc polypeptides of the embodiments and methods for making and using such antibodies are likewise provided. |
| 申请公布号 |
US2015266960(A1) |
申请公布日期 |
2015.09.24 |
| 申请号 |
US201314437544 |
申请日期 |
2013.08.30 |
| 申请人 |
THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM |
发明人 |
Georgiou George;Kelton William;Mehta Nishant |
| 分类号 |
C07K16/28;C07K16/30;A61K47/48;C07K16/00 |
主分类号 |
C07K16/28 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A recombinant polypeptide comprising:
(a) a chimeric CH2 domain comprising a mammalian IgG Fc CH2 domain having a al loop of a mammalian IgA Fc CH2 domain; and (b) a mammalian IgA Fc CH3 domain. |
| 地址 |
Austin TX US |
