ON-LINE SOLID-PHASE EXTRACTION COLUMN WITH MONO-DISPERSION AND HIGH SPECIFIC SURFACE AREA AND PREPARATION METHOD THEREFOR

摘要

Disclosed are an on-line solid-phase extraction column with mono-dispersion and a high specific surface area, and a preparation method therefor, belonging to the field of solid-phase extractions. A membrane emulsification-suspension polymerization method is used to prepare a mono-dispersed styrene-divinylbenzene copolymer microsphere, which then undergoes a Friedel-Crafts reaction to prepare a hypercrosslinked microsphere, and finally the hypercrosslinked microspheres are packed into an on-line SPE microcolumn by an equidensity homogenation method. The membrane emulsification-suspension polymerization method is used in the present invention. The obtained microsphere has a homogeneous particle size and it is convenient to adjust the particle size, crosslinking degree, etc. It is convenient to adjust the specific surface area and surface polarity such that a microsphere having a high specific surface area and a certain polarity can be obtained. The equidensity homogenation method is used to fill the on-line SPE microcolumn, and the obtained microcolumn has an easily adjustable polarity and structure, a small sample amount and a good enrichment and separation effect, can be applied to the liquid-phase chromatographic analysis field, and greatly improves the automation degree of the analysis. The on-line SPE column obtained in the present invention can be applied in the fields of analytical chemistry etc.