| 摘要 |
PROBLEM TO BE SOLVED: To provide compositions, and methods of using such compositions, useful for injection into the posterior segments of human or animal eyes.SOLUTION: The compositions include small particles of a poorly soluble therapeutic agent that facilitates formation of concentrated regions of the therapeutic agent in the retinal pigmented epithelium of an eye. The particles are formed by combining a therapeutic agent with an ophthalmically acceptable polymer component. The particles have sizes less than about 3000 nanometers, and in some cases, less than about 200 nanometers. One example of a composition includes particles of triamcinolone acetonide and hyaluronic acid that have size less than about 3000 nanometers. |
