DEVICES AND METHODS FOR SINGLE CELL ANALYSIS

摘要

The present disclosure provides systems, methods, and devices for the simultaneous determination of a single cell's response to a stimuli and characterization of its cell response. The present disclosure further provides methods for detection of disease state, clinical management of a subject suffering from a disease, drug screening, prediction of drug response, and stands to help direct drug and diagnostic development for the treatment of disease.

主权项

1. A method for detecting a response of a live cell comprising:
(a) contacting a live cell to a cell capture array device, wherein said cell capture array device comprises a cell microenvironment and an inducible agent; (b) capturing said live cell in said cell microenvironment; (c) inducing the release of said inducible agent into said cell microenvironment; and (d) detecting a response of said live cell.