发明名称 |
STREPTOCOCCUS BACTERIOPHAGE LYSINS FOR DETECTION AND TREATMENT OF GRAM POSITIVE BACTERIA |
摘要 |
The present invention provides methods, compositions and articles of manufacture useful for the prophylactic and therapeutic amelioration and treatment of gram-positive bacteria, including Streptococcus and Staphylococcus, and related conditions. The invention provides compositions and methods incorporating and utilizing Streptococcus suis derived bacteriophage lysins, particularly PlySs2 and/or PlySs1 lytic enzymes and variants thereof, including truncations thereof. Methods for treatment of humans are provided. |
申请公布号 |
US2015267185(A1) |
申请公布日期 |
2015.09.24 |
申请号 |
US201514685696 |
申请日期 |
2015.04.14 |
申请人 |
Fischetti Vincent A.;Schmitz Jonathan;Gilmer Daniel;Euler Chad |
发明人 |
Fischetti Vincent A.;Schmitz Jonathan;Gilmer Daniel;Euler Chad |
分类号 |
C12N9/36;A61K45/06;A61K38/47 |
主分类号 |
C12N9/36 |
代理机构 |
|
代理人 |
|
主权项 |
1. A pharmaceutical composition for killing gram-positive bacteria comprising the isolated lysin polypeptide comprising the amino acid sequence of SEQ ID NO:3 or variants thereof having at least 80% identity to the polypeptide of SEQ ID NO:3 and effective to kill the gram-positive bacteria. |
地址 |
West Hempstead NY US |