发明名称 |
METHODS OF TREATING TRANSPLANT REJECTION USING A DOMAIN ANTIBODY DIRECTED AGAINST CD40L |
摘要 |
Methods of treating renal transplant rejection using anti-CD40L domain antibodies are provided. The anti-CD40L dAbs are less likely to cause platelet aggregation and thus cause thromboembolism. Appropriate anti-CD40L dAbs doses and administration regimens are also provided. Combination treatments for transplant rejection, particularly renal transplant rejection, using anti-CD40L dAbs, a CTLA4 mutant molecule (e.g., belatacept) and/or anti-CD28 optionally with conventional immunosuppressive renal transplant therapy are provided. |
申请公布号 |
WO2015143209(A1) |
申请公布日期 |
2015.09.24 |
申请号 |
WO2015US21551 |
申请日期 |
2015.03.19 |
申请人 |
BRISTOL-MYERS SQUIBB COMPANY |
发明人 |
SURI, ANISH;NADLER, STEVEN G.;LARSEN, CHRISTIAN P.;ADAMS, ANDREW B. |
分类号 |
C07K16/28;A61K38/17;A61K39/395;C07K14/705 |
主分类号 |
C07K16/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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