COMPOSITIONS COMPRISING ADIPOSE-DERIVED MESENCHYMAL STEM CELL OVEREXPRESSING GCP-2 GENE FOR TREATING ISCHEMIC DISEASE

摘要

The present invention relates to adipose-derived mesenchymal stem cells (ASCs) overexpressing a granulocyte chemotactic protein-2 (GCP-2) gene. The adipose-derived mesenchymal stem cells according to the present invention overexpress a VEGF-A and an HGF gene to promote angiogenesis, reduce a left ventricular end diastolic diameter (LVEDD) and a left ventricular end systolic diameter (LVESD) value, increase a left ventricular ejection fraction (LVEF) value to improve a cardiac function, and increase vascular density of an ischemic area, thereby being valuably usable in treating an ischemic disease.