发明名称 |
COMPOSITION OF PREVENTING OR TREATING FOR MYOCARDIAL DAMAGE CONTAINING ECHINOCHROMEA |
摘要 |
The present invention relates to a pharmaceutical composition for preventing or treating myocardial damage containing Echinocrome A as an active component, which controls degradation of functions of myocardial cell mitochondria and increase in active oxygen species in myocardial cell caused by a toxic drug for the heart like an anticancer drug, a blood vessel expanding drug, or a drug causing active oxygen species. Accordingly, membrane voltage change of mitochondria, oxygen consumption reduction, and ATP synthesis reduction are prevented or inhibited, and phosphorylation of factors of a cell death signaling process caused by a toxic drug is controlled to present an effect of controlling death of myocardial cells, thereby preventing or treating myocardial damage from a toxic drug. |
申请公布号 |
KR20150106995(A) |
申请公布日期 |
2015.09.23 |
申请号 |
KR20140028994 |
申请日期 |
2014.03.12 |
申请人 |
INJE UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION |
发明人 |
JEONG, SEUNG HUN;SONG, IN SUNG;KIM, HYOUNG KYU;KIM, NA RI;HAN, JIN |
分类号 |
A61K31/122;A61P9/10 |
主分类号 |
A61K31/122 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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