| 摘要 |
A formulation for the topical treatment of joint and/or muscle pain comprising one or more phospholipids and microcapsules containing releasable colourant, wherein the formulation is capable of changing colour upon rupture of the microcapsules. The phospholipids preferably comprise phosphatidylcholine and may be in a nanoemulsion. The colourant is preferably a dye or pigment. The formulation may also contain a further colourant which is different to the colourant in the microcapsules, such that when the microcapsules rupture, the formulation changes from a first colour to a second different colour. The formulation may further comprise an active agent, such as pharmaceutically active ingredients, plant extracts, natural extracts or vitamins. Preferably the formulation comprises a cooling agent such as menthol, or a warming agent such as vanillyl butyl ether and/or methyl salicylate. The formulation may be a gel, cream, lotion, ointment, solution or spray. Also disclosed is a method of treating a patient having joint and/or muscle pain comprising topically applying the formulation to the area of the body affected and massaging the formulation into the skin until the released colour is no longer visible. |
