发明名称 |
Compounds for killing psma-expressing, taxane-resistant cancer cells |
摘要 |
<p>Methods of killing prostate-specific membrane antigen (PSMA)-expressing, taxane-resistant cancer cells are provided. In particular, PSMA-expressing, taxane-resistant cancer cells are contacted with an antibody-drug conjugate (ADC) that comprises an antibody or antigen-binding fragment thereof that specifically binds to PSMA conjugated to monomethylauristatin norephedrine or monomethylauristatin phenylalanine.</p> |
申请公布号 |
EP2727606(A3) |
申请公布日期 |
2015.09.23 |
申请号 |
EP20130182516 |
申请日期 |
2009.09.08 |
申请人 |
PSMA DEVELOPMENT COMPANY, L.L.C. |
发明人 |
MA, DANGSHE;OLSON, WILLIAM, C.;MORRIS, STEPHEN;ISRAEL, ROBERT |
分类号 |
A61K47/48;A61P35/00 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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