Anti-human respiratory syncytial virus (RSV) antibodies and methods of use

摘要

Provided herein are antibodies or antigen-binding fragments thereof that immunospecifically bind to the fusion (F) protein of Respiratory Syncytial Virus (RSV). Also provided are methods for of prevention, treatment and diagnosis of viral infection and/or the treatment of one more symptoms of RSV-mediated disease. Methods of generating antibodies that immunospecifically bind RSV F protein also are provided.

主权项

1. A humanized monoclonal anti-Respiratory Syncytial Virus (RSV) antibody or antigen-binding fragment thereof, wherein the humanized monoclonal anti-RSV antibody or antigen binding fragment thereof comprises:
a variable heavy (VH) chain containing the complementary determining region 1 (CDR1) of SEQ ID NO:405 or SEQ ID NO:437, the complementary determining region 2 (CDR2) of SEQ ID NO:406, and the complementary determining region 3 (CDR3) of SEQ ID NO:407; and a variable light (VL) chain containing the CDR1 of SEQ ID NO: 408, the CDR2 of SEQ ID NO: 409, and the CDR3 of SEQ ID NO:410.