Receiver plate with multiple cross-sections

摘要

A multi-well assembly including a filter plate and receiver plate. Each plate includes a plurality of wells, which, when the filter plate is placed in nesting relationship with the receiver plate, each filter plate well has a corresponding receiver plate well into which it extends. The receiver plate wells are of a non-uniform cross-section in order to increase the gap between the outer walls of the filter plate wells and the inner walls of a corresponding receiver plate well when the receiver plate and filter plate are in nesting relationship. The increased gap size reduces wicking and cross-contamination. A multi-section well of maximum cross-section in an upper region and a minimized cross-section in a lower region, with a gradual transition between the regions, is thus provided. The multi-well assembly of the present invention also improves the repeatability of positioning the filter plate and receiver plate in proper nesting relationship and provides stability during handling, mixing and shaking operations.

主权项

1. A multi-well device comprising:
a filter member having a plurality of filter wells each having a filter well membrane, and a receiver member having plurality of receiver wells each having a bottom, said receiver member adapted to receive said filter member in nesting relationship whereby each of said filter wells extends into a respective receiver well, in one-to-one relationship, to a position spaced from said receiver well bottom, thereby defining in each said receiver well a filter well occupied region and a region unoccupied by a filter well, said filter well occupied region having a diameter larger than any diameter of said region unoccupied by a filter well, each said unoccupied region of each said receiver well comprising a transition region and a remainder region, said transition region being located at a point at or below the location of each said filter well membrane when each said filter well is in nesting relationship with a corresponding receiver well, and located above said receiver well bottom, wherein each receiving well wall in each said transition region is angled radially inwardly, and transitions to a portion of said receiving well wall that does not angle radially inwardly.