Methods of treatment of histamine H-4 receptor-related pruritus

摘要

The methods disclosed herein relate to the treatment of histamine H-4—related pruritus, by administering a histamine H-4 receptor inverse agonist that selectively accumulates at the biophases of the disorders, specifically RS-norketotifen or a pharmaceutically acceptable salt thereof. Potentiated antipruritic activity by simultaneous inhibition of histamine H-1 receptors and histamine H-4 receptors are described.

主权项

1. A method of treating a mammal with selective inverse histamine H-1 agonists, and wherein the histamine H-4 receptor-related pruritus is associated with a dermal disorder selected from autoimmune dermatitis, contact dermatitis, dermal scleroderma, folliculitis, an insect bite, melanoma, parasites, scabies, sunburn, warts, xerosis, moles, and idiopathic pruritus.