| 主权项 |
1. A pharmaceutical composition comprising aripiprazole in a dosage form for transdermal delivery, wherein the composition comprises:
aripiprazole in the amount of 1 to 20% w/v; an enhancer; and a gelling agent in the range of about 0.1% to 5% w/v, said gelling agent selected from the group consisting of natural polymers, semisynthetic polymers, synthetic polymers, carboxyvinyl polymers, carbomers, polyacrylic acid polymers, poloxamer, polyacrylamide, polyvinyl alcohol, polyethylene and co-polymers thereof, and combinations thereof; wherein the dosage form is selected from the group consisting of a patch, an ointment, a cream, an emulsion, and a liposome, and further wherein the pH of the composition is approximately 6 to 7, further comprising approximately 40% N-methyl-2-pyrrolidone, approximately 40% Dimethylsulfoxide, approximately 15% alcohol, and approximately 5% water. |
